R is a popular programming language used by millions of people worldwide for data analysis and visualization. Rmarkdown is a notebook format that allows R users to weave code output and narratives in a single document, and is extremely popular among data scientists for authoring reproducible articles. RStudio is a popular integrated development environment (IDE) that enhances user experience of working with R. In this talk, I will share my top 20 tips and tricks that can help optimize the experience and make working with R, Rmarkdown, and RStudio, faster, easier and intuitive.